| Temporada | Equipo | Competición | PJ | G | A | Nota | ||
|---|---|---|---|---|---|---|---|---|
| 2023/2024 | América | Liga MX | 14 | 0 | 1 | 2 | 0 | 6.9 |
| 2022/2023 | América | Liga MX | 27 | 1 | 7 | 3 | 0 | 7.0 |
| 2021/2022 | América | Liga MX | 27 | 0 | 4 | 7 | 1 | 7.0 |
| 2020/2021 | Monterrey | Liga MX | 32 | 0 | 4 | 4 | 0 | 6.9 |
| 2019/2020 | Monterrey | Liga MX | 30 | 3 | 2 | 4 | 1 | 7.0 |
| 2018/2019 | Monterrey | Liga MX | 11 | 0 | 2 | 1 | 0 | 6.8 |
| 2018/2019 | Villarreal | La Liga | 8 | 0 | 1 | 1 | 0 | 6.8 |
| 2017/2018 | Sevilla | La Liga | 16 | 2 | 0 | 4 | 0 | 6.8 |
| 2017/2018 | Porto | Primeira Liga | 7 | 0 | 0 | 1 | 0 | 6.7 |
| 2016/2017 | Porto | Primeira Liga | 16 | 1 | 3 | 3 | 0 | 7.1 |
| 2015/2016 | Porto | Primeira Liga | 27 | 5 | 13 | 7 | 0 | 7.4 |
| 2015/2016 | Watford | Premier League | 3 | 1 | 0 | 0 | 0 | 6.6 |
| 2014/2015 | Watford | Championship | 17 | 0 | 0 | 2 | 0 | – |
| 2014/2015 | América | Liga MX | 17 | 6 | 0 | 3 | 0 | – |
| 2013/2014 | América | Liga MX | 33 | 5 | 0 | 4 | 0 | – |
| 2012/2013 | América | Liga MX | 33 | 2 | 0 | 1 | 0 | – |
| 2011/2012 | América | Liga MX | 11 | 0 | 0 | 1 | 0 | – |
| 2010/2011 | América | Liga MX | 38 | 1 | 0 | 3 | 1 | – |
| 2009/2010 | América | Liga MX | 10 | 1 | 0 | 1 | 0 | – |
| 2009/2010 | Atalanta | Serie A | 2 | 0 | 0 | 0 | 0 | – |
| 2008/2009 | Veracruz | Liga de Expansión MX | 26 | 1 | 0 | 6 | 0 | – |
| Total | 405 | 29 | 37 | 58 | 3 | – | ||
| Fecha | Desde | Hacia | Tipo | |
|---|---|---|---|---|
| 07 ene 2021 | Monterrey | América | N/A | |
| - | Villarreal | Monterrey | N/A | |
| 07 nov 2018 | Porto | Villarreal | € 3.6M | |
| - | Porto | Sevilla | Loan | |
| 07 ene 2016 | Watford | Porto | € 6M | |
| - | Watford | Porto | Loan | |
| 01 sept 2015 | Granada | Watford | N/A | |
| 01 may 2015 | América | Granada | N/A | |
| 01 ene 2010 | Atalanta | América | Free | |
| 07 ene 2009 | Veracruz | Atalanta | € 900K |
M. Layún career history shows progression across clubs and competitions, including club timeline, national team appearances and overall career totals.